Ahh, the lighter side of life! These are some good webcomics, in no particular order.
comic logo Penny Arcade. Cartoon about gaming, 100% pure.
comic logo 8-bit Theater. Start from the beginning with the archive... Otherwise, you'll never get it.
comic logo Sinfest. Irrevrent. Messes with religious stuff pretty frequently. Very funny.
comic logo User Friendly. Geek stuff. Humor for the helpdesk techs.
comic logo Something Positive. Wierd peeps in wierd social situations. Ummm... Yeah.
comic logo Striptease. Comic about comic strip authors/artists.
comic logo Bob and George! Crazy wacky Mega Man comic. Not about Mega Man by origional intention, I suspect, but it's turned out that way...